Objective: This study aimed to evaluation of formation and development of blastocyst in in-vitro fertilization in women with polycystic ovary syndrome. Methods: Retrospective study on 53 women with PCOS and 52 women with non-PCOS, who underwent in-vitro fertilization with blastocyst culture at Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy Hospital since January 2019 until December 2020. Results: In women with PCOS, ovarian stimulation resulted in a greater number of retrieved oocyte and blastocyst embryos. Study group with PCOS had a statistically significant lower fertilization rate and day-5 embryo rate of 74.8% and 54% compared with those in the control group (84% and 61.2%, respectively). No statistically significant differences were observed in the mature oocyte rate, the good cleavage embryo rate and the pregnancy rate in the group with PCOS compared with the control group. Conclusion: Women with PCOS have higher number of retrieved oocytes after stimulation. The ability to fertilization and quality of blastocyst was lower in the group with PCOS but the potential for implantation and pregnancy rate were similar to the control group after vitrified-warmed embryo transfer. |