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Background: Point mutation A2143G in the 23S rRNA gene were noted as a common mutation in H. pylori resistant to clarithromycine, but data about this point mutations were still limited in Vietnam. This study is aimed at determining the rate of H. pylori eradication of triple therapy RAC and investigating A2143G point mutation in two groups of eradicated and non-eradicated H.pylori. Patients and methods: 90 patients with peptic ulcer or gastritis consulted at Hue University Hospital from Jan 2011 to Dec 2012. Triple therapy used to eradicate H.pylori was RAC in 10 days. A2143G point mutation in the 23S rRNA gene was tested by PCR- RFLP with BsaI enzyme. Results: Eradication rate of the triple therapy RAC in 10 days was 53.3%; the A2143G point mutations was found in 45.2% and 16.7% in two groups of having non-eradication and eradication of H.pylori , respectively. History of clarithromycine usage may be a risk factor of the presence of A2143G point mutation. Conclusion: A2143G point mutation in the 23SrRNA gene may be a risk factor of failure of H.pylori eradication by triple therapy RAC. Key words: A2143G point mutation;23SrRNA gene; clarithromycine resistance.

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