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Tạp chí Y Dược học - Vol 1. No. 1 năm 2012

A Preliminary study of hepatitis B virus genotypes in chronic hepatitis B patients

Tran Xuan Chuong, Ngo Viet Quynh Tram, Huynh Thi Hai Duong, Le Van An

2012 - Vol 1. No. 1, trang 55

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Aim:To study the prevalence of HBV genotypes in chronic hepatitis B patients and their relationship with some clinical and biochemical characteristics. Methods: 60 patients were enrolled in this study from 01/2009 to 06/2010. Clinical, laboratory data were collected at the hospitalized time. Sera were tested for HBeAg, HBV DNA quantitative. HBV genotyping was made by Real-time PCR. Results: Among the 60 patients, 38 patients (63.3%) had genotype B, 16 (26.7%) had genotype C and 6 have mixed genotype B-C (10%). Genotype B was predominant in group under 30 yrs (47.4%), but genotype C in group > 30-40 yrs (50%). 43.8% pts of genotype C had fatigue. About 50% of genotype C but only 31% of genotype B had ALT level higher than 5 times upper limit. In genotype C group, 41.7% patients had HBV DNA level higher than 107copies/ml. Conclusions: Most of the patients had genotypes B or C. In patients with CHB, patients of genotype C tended to have more severe necroinflammation and higher serological HBV DNA level than genotype B.

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Tran Xuan Chuong, Ngo Viet Quynh Tram, Huynh Thi Hai Duong, Le Van An. (2012). A Preliminary study of hepatitis B virus genotypes in chronic hepatitis B patients. Tạp chí Y Dược học, , 55.

A Preliminary study of hepatitis B virus genotypes in chronic hepatitis B patients

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