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Objectives: To survey S100Β blood concentrations in patients with acute phase cerebral infarction. To understand the relationship between blood concentrations of S100Β and a number of other risk factors such as age, gender, occupation, the coma state as measured by the Glasgow coma scale and the severity of lesions on computerized tomography. Subjects and Methods: The study examined 32 cerebral infarction patients hospitalized at intensive care unit of Hue Central Hospital. Data collection was conducted through medical records of patients with cerebral infarction. The study is cross-sectional and descriptive. Statistical analysis of the data was carried out using the SPSS 16.0 software. Results: The majority of patients were aged from 61 to 80 years-old (53.12%) and were elderly retirees. The association between S100Β concentrations and age appeared to be positive, with higher concentrations found in older patients, but this relationship was not significant (p> 0.05). The concentrations of S100B also appeared to be highest for patients with Glasgow coma scale ratings of 7-9 (mean concentration=2.04 ± 2.68). Thus it appeared that the concentration increased with the severity of the coma state. However, the difference was not statistically significant (p> 0.05). There were six cases of S100Β-positive but CT scan results were negative because the scans were taken too early (before 24 hours of injury). However there were two of 26 cases that produced a positive CT scan for cerebral infarction but not increased S100Β. The larger the volume of brain lesions, the higher the concentration of S100Β. There was a strong correlation between S100Β concentration and lesion volume, with the following correlation equation: y = 35.497x +53.702; and correlation coefficient: r = 0.521, p <0.01. Conclusion: Increased blood concentration of S100Β appeared earlier than positive computerized tomography in patients with acute-phase cerebral infarction. Patients in a deeper state of coma had increased S100β. The older a patient, the higher was the concentration of S100β. Age of patients was mostly between 61-80 years old (average 68.19 ± 13.29). Most were retired pensioners. There was a strong agreement on the correlation between S100β concentration and lesion volume.

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