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Background: This sutdy aimed at investigating the relationship between effectiveness of 3 months - combination therapy Atorvastatin plus Aspirin in patients with acute cerebral infarction on inflammatory factors (hs-CRP, fibrinogen) and the progression of carotid atherosclerosis. Patients and Metho: Clinical research trials and longitudinal follow-up, 66 patients with acute cerebral infarction treated at Hue University Hospital. Data were processing by conventional statistics methods and SPSS 15.0. Results: 1. The concentration of hs-CRP, serum fibrinogen, Intimal-Medial Thickness (IMT) and carotid atherosclerosis in patients with acute cerebral infarction highly increased: hs-CRP was 6.46 ± 4.49 mg/l; fibrinogen was 4.59 ± 1.52 g/l; carotid IMT was 1.67 ± 0.72 mm and carotid atherosclerosis was 2.88 ± 1.24 mm. 2. The effective coordination of Atorvastatin therapy plus aspirin versus aspirin therapy alone: (i) Effect of serum hs-CRP levels between the two groups after 1 month of treatment was (1.60 ± 0.65 vs. 4.11 ± 2.54 mg l) with paired t -3.06 and p <0.05; effect after 3 months was (1.26 ± 0.53 compared with 3.24 ± 3.03 mg/l) with paired t -3.85 and p <0.01; (ii) Effect of fibrinogen concentration between the two groups after 1 month of treatment was (2.80 ± 0.93 vs. 3.30 ± 0.73 g/l) with paired t -2.41 and p <0.05; effect after 3 months (2.67 ± 0.79 vs. 3.09 ± 0.59 mg/l) with paired t -2.58 and p <0.01; (iii) Treatment effectiveness on IMT and carotid atherosclerosis between the combination therapy group compared with the monotherapy: improvement effect of IMT (t paired -2.06 and p <0.05) and carotid atherosclerosis (t paired -3.04 and p <0.01). Conclusion: Patients with acute cerebral infarction treated by combination therapy of Atorvastatin plus Aspirin significantly reduced the concentration of inflammatory factors hs-CRP, fibrinogen and carotid atherosclerosis progression. Key words: carotid atherosclerosis, acute cerebral infarction, inflammation

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