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Background: Besides tPSA, the f/t PSA ratio plays a meaningful role for the orientation of diagnosis and the screening of the prostatic diseases, especially for the 2 most frequent ones including prostatic carcinoma and benign nodular hyperplasia. Objectives: - To compare the average mean of the f/t PSA in the patient with the prostatic carcinoma and benign nodular hyperplasia; - To determine the diagnostic value of the f/t PSA in prostatic carcinoma. Materials and Method: Cross-sectional study on 70 patients including 35 cases with benign nodular prostatic hyperplasia and 35 ones with carcinoma of the prostate. Results: The average mean of the fPSA in the patient with the prostatic carcinoma was higher than ones with the benign nodular hyperplasia (7.06ng/ml, 1.08ng/ml respectively); The f/t PSA ratio of prostatic carcinoma (0.15) was lower than ones of benign nodular hyperplasia (0.25); in most patients with benign nodular hyperplasia the f/t PSA ratio was over 0.19 (88%), otherwise in the PC group it was below 0.19 (71.11%). With the cut-off value of 0.19 of the f/t PSA ratio, the sensitivity, specificity, accuracy were 91.43%, 62.85% and 77.14% respectively. Conclusions: f/t PSA Ratio should be applied for the diagnosis and the screening of the prostatic tumors apart from the tPSA test.

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