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Background: The aim of this study was to formulate artesunate (ART)-loaded EudragitR RS PO (Eudragit)­ based nanoparticles (NPs) as well as to evaluate their physiochemical characteristics; Materials and methods: The NPs were fabricated by the emulsion evaporation method. The effects of several formulation parameters on the physicochemical properties of NPs were investigated including ART content, Eudragit concentration, the ratio of oil phase and water phase (0/W), and Tween 80 concentration (%, w/ v). The size distribution of NPs was measured by means of dynamic light scattering (DLS). The morphology of NPs was investigated by scanning electron microscopy (SEM). The in vitro drug release was studied by a dialysis method; Results: The best formulation  showed  a spherical  shape with the size of about 170  nm, POI of 0.240  and zeta  potential of 53.6 mV. Encapsulation efficiency and loading capacity of NPs were 88.56% and 18.64%, respectively. The drug release profile in phosphate buffer of pH 7.4 was characterized by a biphasic pattern with initial burst release followed by a sustained release; Conclusion: The Eudragit NPs could be potential as carriers in the cancer therapy of ART.

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