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Introduction: Hand-foot-and-mouth disease (HFMD) is a viral infection of infants and young children worldwide. The disease is caused by enteroviruses A of the family Picornaviridae including coxsackievirus A6 (CV-A6), CV-AlO, CV-A16 and enterovirus A71 (EV-A71). Aims: to determine the proportions of EVs and EV­ A71 from the children patients with HFMD and the clinical characteristics of HFMD cases in Central Vietnam. Methods: 97 throat swabs abstained from children patients suspected of HFMD; collected data from the patients by a clinical doctor in a case-recorded form for demographic data, clinical features; detected entero­ viruses and enterovirus A71 by the in-house multiplex real-time RT-PCR. Results: the proportions of EVs and EV-A71 causing HFMD in the children patients in Central Vietnam were 60.8% and 4.1%, respectively. The clinical characteristics of HFMD reported in most cases were fever (95.9%), followed by oral ulcers (50.1%); symptoms of rashes, vomiting and myoclonus were present in 27.8%,17.5% and 9.3% of cases, respectively; there was no case involving the central nervous system or pulmonary edema. Conclusion: From May 2015 to August 2015, there were 60.8% of HFMD cases of infected with enteroviruses in Central Vietnam, only 4.1% of cases infected with enterovirus A71. No case involved the central nervous system or pulmonary edema.

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