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Background: Early diagnosis of acute coronary syndrome (ACS) is significant to treatment and prognosis. It helps to reduce death and complications. What is the value from a combination of ischemia modified al­ bumin (IMA) and hs-Troponin T(hs-TnT) for diagnosis of non-ST segment elevation acute coronary syndrome (NSTE-ACS)? Objectives: Determining the concentration of IMA and hs-TnT in patients with NSTE-ACS; Deter­ mining sensitivity and specificity when combining IMA and hs-TnT in diagnosis of non-ST segment elevation acute coronary syndrome. Subjects and Method: 75 patients were hospitalized in Hue Central Hospital with chest pain, presenting non-ST segment elevation acute coronary syndromes. Diagnosis of non-ST segment elevation acute coronary syndromes was done on 37 of those as in a patients group; 38 others were chosen as a controls group. Cross-sectional study with comparison was applied. Results:- In 2 tests at different time points, the concentration of hs-TnT and IMA in patients group with NSTE-ACS was higher compared with that in the controls group (median: 0.065ng/ml >0.006ng/ml and 0.162ng/ml >0.00SSng/ mL); Average IMA concentration in patients group was 93.49± 89.56 IU/ml (median: 58.57IU/ml) and higher compared with the controls group which reaches 15.01 ± 9.87 IU/ml (median:11.735IU/ml). It resulted in a statistical sig­ nificance p<0.001.-The cut off point of hs-TnT was> 0.014ng/ml and IMA>28.68 IU/ ML, reaching a sensitivity at 88.9% and a specificity at 100%, AUC = 0.97, p < 0.001, 95% Cl= 0.915 -1.00. Conclusion : Combination of IMA and hs-TnT results in a high value for diagnosis of non-ST segment elevation acute coronary syndromes.

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