Tạp chí Y Dược học - No. 4 năm 2013
Le Chuyen, Nguyen Hai Thuy, Hoang Khanh, Le Van An, Le Thanh Hai, Duong Thi Ngoc Lan, Nguyen Vu Lam Yen
2013 - No. 4, trang 72
Background: The relationship between the concentration of serum ferritin, transferrin, iron and their prognostic value for patients with cerebral infarction during the acute phase.
Subjects and Methods: Cross-sectional descriptive methods, 104 cases including 52 patients with cerebral infarction and 52 control subjects in Hue University Hospital. Data were processed by usual medical statistics and SPSS 15.0.
Results: Mean age of cerebral infarction group was 64.90 ± 11.85 and 65.17 ± 11.48 in control group (p > 0.05). (i) In cerebral infarction group, ferritin concentration (378.4 mg/L) and iron concentration (25.2 mmol/L) were, higher than the control group (p < 0.001 and p < 0.01, respectively). There was no difference in transferrin concentration between patient group and the control group (p > 0.05); (ii) Ferritin concentrations had good diagnostic value with confidence interval of 95% (0.784 - 0.924), AUC was 0.862. Iron had little diagnostic value than ferritin in cerebral infarction patients with confidence interval of 95% (0.564 - 0.753), AUC was 0.664; (iii) Analysis of multivariate logistic regression showed that both ferritin and iron have used to predict cerebral infarction (Glasgow = 15), AUC was 0.768 with a sensitivity and specificity of 77.78% and 64%, respectively; (iv) Ferritin levels correlated with cerebral infarction lesion size > 2cm, higher than serum iron, with AUC was 0.91. With the choice of cut-off point ≥ 403.1, specificity was high (approximately 92%).
Conclusions: The concentration of serum ferritin, iron was high and correlated with severity in cerebral infarction patients with acute phase.
Le Chuyen, Nguyen Hai Thuy, Hoang Khanh, Le Van An, Le Thanh Hai, Duong Thi Ngoc Lan, Nguyen Vu Lam Yen. (2013). Predictive value of serum ferritin, transferrin, iron concentration for prognostic in patients with acute phase cerebral infarction. Tạp chí Y Dược học, , 72. DOI: 10.34071/jmp.2012.2e.11
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