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Background: Primary nephrotic syndrome is a disease of chronic glomerulonephritis. In addition to the nephrotic syndrome manifested as loss of protein in the urine, decreased blood proteins, blood coagulation disorders are also manifestations of dyslipidemia. It has documented some cases of death in patients with nephrotic syndrome are related to dyslipidemia. Many authors have suggested the drug combination to treat dyslipidemia in nephrotic syndrome. Methods: We selected 38 patients of primary nephrotic syndrome treated with dose of 1mg/kg prednisolon in combination with statin of 10 mg/day in period of 4 continuous weeks. Results: The results showed that the average TC concentrations decrease during treatment, with p <0.001: after 4 weeks, the average concentration was 5.77 ± 1.76 mmol/l and the rate of patients having TC concentrations at risk accounted for 28.95%. Average TG concentration was lower than before treatment, after 4 weeks, the average concentration was 2.35 ± 2.36 mmol/l, the proportion of patients at risk accounted for 36.84%. The average concentration of LDL was lower than before treatment, after 4 weeks, average concentration was 3.26 ± 1.87 mmol/l, 21.05% patients were at risk. The average concentration of HDL increased compared to before treatment and returned to acceptable levels after 2 and 4 weeks, after 2 weeks of treatment, most patients have a good HDL level, accounting for 97.37%.

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