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Objectives: Rheumatoid arthritis is the most common chronic arthritis. Although its etiology remains unclearly, various cytokines are known to play key roles as mediators that induce abnormality. Subjects and Methods: Determine the correlation between levels of serum IL-1α,IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN-γ, TNF-α, MCP1, EGF which clinical factors: disease duration, the number of damaged joint , DAS 28 as well as clinical factor: CRP,VS in patients whith rheumatoid arthritis. Subject and methods: The research in 76 patients with rheumatoid arthritis was diagnosed according to ACR/EULAR 2010, were examined to determine the disease duration as well as the number of damaged joints, take quantitative blood and serum concentrations of cytokines (IL-1α,IL-1β, IL- 2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN-γ, TNF-α, MCP1, EGF), CRP, and VS. Result: The average of cytokines serum concentrations in patients with rheumatoid arthritis are (IL-1α,IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN-γ, TNF-α, MCP1, EGF), (5,09; 10,73; 33,08; 6,62; 31,95; 79,92; 12,67; 549,21; 16,68; 15,90; 243,23; 115,17). Disease duration correlated with IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN-γ, TNF-α, MCP1. Was correlated the number of damaged joint were correlated with IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ, TNF-α. DAS 28 was correlates with IL-1α, IL-1β, IL-2, IL-4 , IL-6, IL-8, IL-10, IFN-γ, TNF-α . CRP correlated with IL-1α, IL-1β, IL-2 , IL-4 , IL-6, IL-10, IFN-γ , TNF-α.VS correlates with IL-1α, IL-1β, IL-2 , IL-4, IL-6, IL-10, IFN-γ, TNF-α . EGF wasn’t correlated with disease duration, the number of damaged joint, DAS 28 as well as clinical factor: CRP,VS.

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