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A series of PAMAM dendrimer generation 5-poly (acrylic acid) grafts were prepared to evaluate the potential use of dendritic grafts as a drug encapsulated nanocarrier. The structural features of the synthesized polymer graft were identified by FT-IR and 1H-NMR spectra and the biophysical properties were characterized by measuring its particle size and zeta potential. The prepared dendrimer G5–PAA grafts have a particle size in the range of 600 to 900 nm and the size gets bigger as the number of PAA on the dendrimer surface increases. The electrostatic property of the dendrimer G5-PAA, carried out by HPLC reversed phase column analysis and the measurement of zeta potential, revealed that both migration time and zeta potential were dependent on the number of grafted PAA. The number of free amino groups on dendrimer G5-PAA, determined quantitatively by fluorescamine assay, was in a reverse order with the reaction mole ratio of dendrimer to PAA. In addition, dendrimer G5-PAA had a pH-dependent solubility in aqueous solution with low solubility at pH 4.7 to 7.8. Keywords: Dendrimer, poly(acrylic acid), dendrimer G5-PAA, graft

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