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Tạp chí Y Dược học - Vol 1. No. 1 năm 2012

Malaria morbidity reduces in a population of hemoglobin E carriers

Huynh Dinh Chien, Francis Fumoux, Vo Duy Kim

2012 - Vol 1. No. 1, trang 178

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The ability of protection of Hemoglobin E (HbE) against malaria caused by Plasmodium falciparum is still in debate. We have recognized the existence of an abnormal Hb in a severe pandemic area of malaria. All malarial patients hospitalized at the health Post of Thanh Commune in the epidemic season of 2003 were included in the study. For the control group (n=157), the frequency of HbE gene is 47% including 22% of EE and 51% of AE gene. These proportions are similar to those reported in general population of Van Kieu ethnic minority (43% and 50% respectively). For the malarial patients group (n=45), the frequency of HbE gene was 31% including 9% of EE and 44% of AE. Both control and patients groups were similar in the aspects of age and sex. The frequency of AA gene carrier was higher significantly in the patient group (p<0.03). These results show that the presence of HbE genotype may have a protection role against malaria.

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Huynh Dinh Chien, Francis Fumoux, Vo Duy Kim. (2012). Malaria morbidity reduces in a population of hemoglobin E carriers. Tạp chí Y Dược học, , 178.

Malaria morbidity reduces in a population of hemoglobin E carriers

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