Tạp chí Y Dược học - No. 4 năm 2013
Hoang Bao Nhan, Nguyen Vu Quoc Huy
2013 - No. 4, trang 86
Background: It is estimated that 10-20% of term babies were born with meconium stained amniotic fluid (MSAF), and the rates of mortality and morbidity of this group were higher than those with clear fluid. This study aimed to estimate risk factors and to assess outcomes of term pregnancies with MSAF.
Materials & methods: A cross-sectional descriptive study, implemented from April, 2011 to July, 2012 on 368 term pregnancies with MSAF and 373 others with clear fluid as controls group. Inclusion criteria were singleton pregnancies with gestational age (GA) from 38 weeks 0 day to 41 weeks 6 days, cephalic presentation. Exclusion criteria were pregnancies with malformation fetus, could not estimated the GA, and the women who had cardiotocography (CTG) shorter than 30 minutes. Odd-ratios (OR) were used to calculate the difference between the two groups in the rate of maternal age (MA) older than 30 years old, postdate pregnancies, PROM, labor in active phase, and the rate of abnormal CTG. The difference between the two groups in the rate of Cesarean section (C-section) was calculated by risk-ratio (RR). Logistic regression model was used to find out some models to predict the potential of acidosis in newborns from pregnancies with MSAF.
Results: Maternal age greater than 30 and post date pregnant are risk factors of MSAF with odds-ratio are 4.02 (95% CI: 2.95 - 5.48) and 3.94 (95% CI: 2.84 - 5.48), respectively. PROM and labor in active phage are not risk factors of the disorder. The rate of abnormal CTG is 5.47 (95% CI: 3.57 - 8.38) when the rate of C-section is 2.1 (95%CI: 1.72 - 2.57) times higher than clear fluid group. The rate of acidemia is 7.1%, and 4.93 (95%CI: 1.83 - 10.54) times higher than controls. CTG type 3 is the sign in which we can predict the acidemia of these babies with 96.2% accuracy rate. But these with only 93.5% if there are type 2 CTG and thick-green meconium.
Conclusions: In term pregnancies, maternal age older than 30 and postdate pregnancies are risk factors of MSAF. This group of pregnancies has higher rate of abnormal CTG, C-section, and acidemia babies.
Hoang Bao Nhan, Nguyen Vu Quoc Huy. (2013). Meconium stained amniotic fluid in term pregnancies: A study on risk factors and outcomes. Tạp chí Y Dược học, , 86. DOI: 10.34071/jmp.2012.2e.14
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