Tóm tắt

Background: Couples with two or more miscarriages are at increased risk of carrying a chromosomal abnormality, especcially a structural chrosome abnormality with balanced karyotype. This study is aimed at (1) Determining the incidence of chrmosomal abnormalities in couples with two and more miscarriages and (2) Assessing the relationship between chrmosomal abnormalities and some features of miscarriage. Patients and Methods: One hundred and twenty couples with two and more miscarriages were enrolled for karyotyping. Results: The incidence of chromosomal abnormality in couple with two and more miscarriage was found in 5%. chromosomal abnormalities were reciprocal translocation 50%, Robertsonian translocation 16.7%, inversion 16.7% and numercial abnormalities of sex chromosome 16.7%. The rate of having family history on two or more miscarriage in the group of abnormal chromosome was 75%, but it is only 3.9% in the normal group, p>0.0001. In the group of abnormal chromosome, the rate of 8-12 weeks gestation was the highest, 75%, and only 40% in the normal group, p= 0.0173. Conclusion: The rate of reciprocal translocation was the highest among chromosomal abnormalities. There was a relationship between chromosomal abnormalities and family history and gestation. Key words: chromosomal abnormalities, miscarriage

Từ khoá

Toàn văn

PDF

Trong số này