Objectives: To study the left ventricular myocardial function with two-dimensional speckle tracking echocardiography and the concordance of endocardial 2DSTE and coronary angiography on the localization of coronary artery stenosis.

Subjects and methods: A cross-sectional study was conducted in 60 patients with coronary artery disease at Hue University of Medicine and Pharmacy Hospital. All of them were examinated 2DSTE (using endocardial layer strain analysis) and coronary angiography.

Results: 60 patients (34 men, 26 women, 69.08 ± 12.44 yrs), statistically significant 2D-STE reduction of the deformation parameters: global longitudinal strain (GLS) (−8.84% ± 4.74, p < 0.05); global circumferential strain (GCS) (−12.49% ± 6.02, p < 0.05). The agreement of the GLS segment and coronary artery stenosis by coronary angiography were k=0.34 (p < 0.05) at anterior wall, k = 0.53 (p < 0.05) at lateral wall, k = 0.24 (p < 0.05) at inferior wall.

Conclusions: The study using strain on 2DSTE shows the left ventricular systolic function reduced in patients with CAD. There is a various agreement (not good) about the location of coronary lesions between 2D STE (endocardial strain analysis) and coronary angiography.