Background: In Vietnam, a number of recent epidemiological studies demonstrated that the prevalence of antibiotic-resistant bacteria has been rapidly increasing, especially in intensive care units (ICUs). The implementation of comprehensive and long-term measures through antibiotic stewardship programs (AMS) is necessary.

Objectives: For patients in the ICU of Hue University of Medicine and Pharmacy Hospital: (1) To survey of usage of antibiotics, and (2) to find out patient-related factors for antibiotic use.

Materials and methods: A cross-sectional study was carried out on 102 medical records of patients who were treated in the ICU from 01/2019 to 10/2020, at Hue University of Medicine and Pharmacy Hospital.

Results: The average age of patients was quite high at 70.71±19.70 years. Initial antibiotic with monotherapy accounted for 41.2%, mainly was ceftriaxone (28 prescribed), combined two antibiotics accounted for 49.0%, the most popular was the combination of third generation cephalosprins with fluoroquinolones. Most of participants prescribed a total of two or three types of antibiotics in their medical records (accounted for 68.6%). Patient-related factors associated with antibiotics usage included: antibiogram results (OR=4.7, p=0.039), sepsis diagnosis (OR=12.0, p=0.04), and initial therapeutic change (OR=14.5, p=0.002).

Conclusion: The majority of initial antibiotic therapies are monotherapy and a combination of two antibiotics in accordance with the recommendation. The number of used antibiotics were associated with the sepsis diagnosis, antibiogram results, and changing antibiotic therapy